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Does how speakers are mounted in the cabinet effect the sound in any appreciable way?

Yes. I find that front-mounted speakers sound thinner and don't cause the cabinet to resonate as much. If you rear mount your speakers, you'll get more fundamental tone and less crap.

I've asked this question many times, and gotten many answers-I know Mesa front loads most of their speakers in cabs- Marshall usually rear loads them-there is some research into this topic, but not alot that is conclusive.

Front mounting drivers is usually only important for speakers reproducing high-frequency sounds or ones with multiple drivers for coherence. As far as guitar speakers, they don't play high enough to make that huge of a difference, dispersion is affected negatively by shooting the sound through a quot;tubequot; but it's not really as big a deal as you'd think.

Technically, having the driver mounted perfectly aligned with the front baffle is the correct way to mount drivers.