software

Hey gang. I'm having a problem with my axe making a sort of clicking/whirring noise while I play. I can record and upload a clip of the sound later, but right now it's pretty late. I only hear it when I have distortion turned on, and it only occurs in a certain spot. It's most audible when I play a high E at the 12th fret. When I play the same note with a harmonic instead of fretting, the noise isn't there. I don't get why it's happening. Could it have something to do with the pickup or a bad switch? Is it a really quiet fret buzz? Any help is appreciated.

My guitar is a Peavey V-Type with a floyd rose trem and a Dimarzio D-Sonic in the bridge (I hear the noise most with the bridge pup). If the action needs to be adjusted, I need to know how to change the saddle height. Thanks.